Ontology highlight
ABSTRACT:
SUBMITTER: Rolland SG
PROVIDER: S-EPMC3740885 | biostudies-other | 2013 Aug
REPOSITORIES: biostudies-other
Rolland Stéphane G SG Motori Elisa E Memar Nadin N Hench Jürgen J Frank Stephan S Winklhofer Konstanze F KF Conradt Barbara B
Proceedings of the National Academy of Sciences of the United States of America 20130722 32
Mitochondrial morphology changes in response to various stimuli but the significance of this is unclear. In a screen for mutants with abnormal mitochondrial morphology, we identified MMA-1, the Caenorhabditis elegans homolog of the French Canadian Leigh Syndrome protein LRPPRC (leucine-rich pentatricopeptide repeat containing). We demonstrate that reducing mma-1 or LRPPRC function causes mitochondrial hyperfusion. Reducing mma-1/LRPPRC function also decreases the activity of complex IV of the el ...[more]