Ontology highlight
ABSTRACT:
SUBMITTER: Ambrus AM
PROVIDER: S-EPMC3866969 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Ambrus Aaron M AM Islam Abul B M M K AB Holmes Katherine B KB Moon Nam Sung NS Lopez-Bigas Nuria N Benevolenskaya Elizaveta V EV Frolov Maxim V MV
Developmental cell 20131101 4
E2F/DP transcription factors regulate cell proliferation and apoptosis. Here, we investigated the mechanism of the resistance of Drosophila dDP mutants to irradiation-induced apoptosis. Contrary to the prevailing view, this is not due to an inability to induce the apoptotic transcriptional program, because we show that this program is induced; rather, this is due to a mitochondrial dysfunction of dDP mutants. We attribute this defect to E2F/DP-dependent control of expression of mitochondria-asso ...[more]