Ontology highlight
ABSTRACT:
SUBMITTER: Klingstedt T
PROVIDER: S-EPMC3743175 | biostudies-other | 2013 Mar
REPOSITORIES: biostudies-other
Klingstedt Therése T Blechschmidt Cristiane C Nogalska Anna A Prokop Stefan S Häggqvist Bo B Danielsson Olof O Engel W King WK Askanas Valerie V Heppner Frank L FL Nilsson K Peter R KP
Chembiochem : a European journal of chemical biology 20130228 5
Small hydrophobic ligands identifying intracellular protein deposits are of great interest, as protein inclusion bodies are the pathological hallmark of several degenerative diseases. Here we report that fluorescent amyloid ligands, termed luminescent conjugated oligothiophenes (LCOs), rapidly and with high sensitivity detect protein inclusion bodies in skeletal muscle tissue from patients with sporadic inclusion body myositis (s-IBM). LCOs having a conjugated backbone of at least five thiophene ...[more]