Ontology highlight
ABSTRACT:
SUBMITTER: Holmes BB
PROVIDER: S-EPMC3746848 | biostudies-other | 2013 Aug
REPOSITORIES: biostudies-other
Holmes Brandon B BB DeVos Sarah L SL Kfoury Najla N Li Mei M Jacks Rachel R Yanamandra Kiran K Ouidja Mohand O MO Brodsky Frances M FM Marasa Jayne J Bagchi Devika P DP Kotzbauer Paul T PT Miller Timothy M TM Papy-Garcia Dulce D Diamond Marc I MI
Proceedings of the National Academy of Sciences of the United States of America 20130729 33
Recent experimental evidence suggests that transcellular propagation of fibrillar protein aggregates drives the progression of neurodegenerative diseases in a prion-like manner. This phenomenon is now well described in cell and animal models and involves the release of protein aggregates into the extracellular space. Free aggregates then enter neighboring cells to seed further fibrillization. The mechanism by which aggregated extracellular proteins such as tau and α-synuclein bind and enter cell ...[more]