Immunoglobulin genes and the acquisition of HIV infection in a randomized trial of recombinant adenovirus HIV vaccine.

ABSTRACT: Our knowledge of the host genetic factors that contribute to the acquisition of HIV infection is limited. To identify the host genetic correlates of HIV1 acquisition, we genotyped 777 participants of a randomized trial of recombinant adenovirus HIV1 vaccine for Fc? receptor IIa (Fc?RIIa), Fc?RIIIa, and several GM and KM alleles-genetic markers of immunoglobulin ? and ? chains, respectively. None of the genotypes by itself was significantly associated with the acquisition of HIV1 infection. However, particular combinations of GM and KM as well as those of GM and Fc?RIIIa loci were significantly associated with the acquisition of HIV1 infection epistatically: KM1/3-GM3/17 (interaction p=0.0246; FDR=0.2952), KM1/3-GM5/21 (interaction p=0.0016; FDR=0.0960), and GM23+/-Fc?RIIIa (interaction p=0.0060; FDR=0.1200). These results suggest the involvement of GM, KM, and Fc?RIIIa loci in the acquisition of HIV infection. Additional studies are warranted.

SUBMITTER: Pandey JP 

PROVIDER: S-EPMC3750738 | biostudies-other | 2013 Jun

REPOSITORIES: biostudies-other