Ontology highlight
ABSTRACT:
SUBMITTER: Levy SL
PROVIDER: S-EPMC3755366 | biostudies-other | 2008 Nov
REPOSITORIES: biostudies-other
Levy Stephen L SL Mannion John T JT Cheng Ji J Reccius Christian H CH Craighead Harold G HG
Nano letters 20081010 11
Single DNA molecules confined to nanoscale fluidic channels extend along the channel axis in order to minimize their conformational free energy. When such molecules are forced into a nanoscale fluidic channel under the application of an external electric field, monomers near the middle of the DNA molecule may enter first, resulting in a folded configuration with less entropy than an unfolded molecule. The increased free energy of a folded molecule results in two effects: an increase in extension ...[more]