Ontology highlight
ABSTRACT:
SUBMITTER: Feng X
PROVIDER: S-EPMC3757334 | biostudies-other | 2013 Sep
REPOSITORIES: biostudies-other
Feng Xuyang X Luo Zhenhua Z Jiang Shuai S Li Feng F Han Xin X Hu Yang Y Wang Dan D Zhao Yong Y Ma Wenbin W Liu Dan D Huang Junjiu J Songyang Zhou Z
Journal of cell science 20130626 Pt 17
The majority of cancer cells rely on elevated telomerase expression and activity for rapid growth and proliferation. Telomerase-negative cancer cells, by contrast, often employ the alternative lengthening of telomeres (ALT) pathway to maintain telomeres. ALT cells are characterized by long and dynamic telomeres and the presence of ALT-associated promyelocytic leukemia (PML) bodies (APBs). Previous work has shown the importance of APBs to the ALT pathway, but their formation and precise role rema ...[more]