Ontology highlight
ABSTRACT:
SUBMITTER: Yoshikawa T
PROVIDER: S-EPMC3759383 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Yoshikawa Takeshi T Otsuka Motoyuki M Kishikawa Takahiro T Takata Akemi A Ohno Motoko M Shibata Chikako C Kang Young Jun YJ Yoshida Haruhiko H Koike Kazuhiko K
PloS one 20130902 9
A widespread downregulated expression of microRNAs (miRNAs) is commonly observed in human cancers. Similarly, deregulated expression of miRNA-processing pathway components, which results in the reduction of global miRNA expression, may also be associated with tumorigenesis. Here, we show that specific ablation of Dicer1 in intestinal epithelial cells accelerates intestinal inflammation-associated tumorigenesis. This effect was apparent only when a single copy of Dicer1 was deleted, but not with ...[more]