Ontology highlight
ABSTRACT:
SUBMITTER: Melo SA
PROVIDER: S-EPMC4509508 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Melo Sonia A SA Ropero Santiago S Moutinho Catia C Aaltonen Lauri A LA Yamamoto Hiroyuki H Calin George A GA Rossi Simona S Fernandez Agustin F AF Carneiro Fatima F Oliveira Carla C Ferreira Bibiana B Liu Chang-Gong CG Villanueva Alberto A Capella Gabriel G Schwartz Simo S Shiekhattar Ramin R Esteller Manel M
Nature genetics 20090215 3
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by targeting messenger RNA (mRNA) transcripts. Recently, a miRNA expression profile of human tumors has been characterized by an overall miRNA downregulation. Explanations for this observation include a failure of miRNA post-transcriptional regulation, transcriptional silencing associated with hypermethylation of CpG island promoters and miRNA transcriptional repression by oncogenic factors. Another possibility is that the ...[more]