Ontology highlight
ABSTRACT:
SUBMITTER: Berthier A
PROVIDER: S-EPMC3767515 | biostudies-other | 2013 Sep
REPOSITORIES: biostudies-other
Berthier Arnaud A Jiménez-Sáinz Judit J Pulido Rafael R
Proceedings of the National Academy of Sciences of the United States of America 20130819 36
Mutations in PTEN-induced putative kinase 1 (PINK1) gene are associated to early-onset recessive forms of Parkinson disease. PINK1 function is related to mitochondria homeostasis, but the molecular pathways in which PINK1 is involved are largely unknown. Here, we report the identification of the embryonic ectoderm development polycomb histone-methylation modulator (EED/WAIT1) as a PINK1-interacting and -regulated protein. The PINK1:EED/WAIT1 physical interaction was mediated by the PINK1 kinase ...[more]