Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC2966406 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Li Qiang Q Wang Xiuhong X Lu Zheming Z Zhang Baozhen B Guan Zhenpo Z Liu Zhaojun Z Zhong Qiming Q Gu Liankun L Zhou Jing J Zhu Budong B Ji Jiafu J Deng Dajun D
PloS one 20101029 10
<h4>Background</h4>H3K9 trimethylation (H3K9me3) and binding of PcG repressor complex-1 (PRC1) may play crucial roles in the epigenetic silencing of the p16 gene. However, the mechanism of the initiation of this trimethylation is unknown.<h4>Methodology/principal findings</h4>In the present study, we found that upregulating the expression of PRC1 component Cbx7 in gastric cancer cell lines MGC803 and BGC823 led to significantly suppress the expression of genes within the p16-Arf-p15 locus. H3K9m ...[more]