Ontology highlight
ABSTRACT:
SUBMITTER: Cohen D
PROVIDER: S-EPMC3771104 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Cohen Danielle D Colvin Robert B RB Daha Mohamed R MR Drachenberg Cinthia B CB Haas Mark M Nickeleit Volker V Salmon Jane E JE Sis Banu B Zhao Ming-Hui MH Bruijn Jan A JA Bajema Ingeborg M IM
Kidney international 20120201 7
The introduction of C4d in daily clinical practice in the late nineties aroused an ever-increasing interest in the role of antibody-mediated mechanisms in allograft rejection. As a marker of classical complement activation, C4d made it possible to visualize the direct link between anti-donor antibodies and tissue injury at sites of antibody binding in a graft. With the expanding use of C4d worldwide several limitations of C4d were identified. For instance, in ABO-incompatible transplantations C4 ...[more]