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New hope for therapy in neurodegenerative diseases.


ABSTRACT: The use of genetic screens to define cellular pathways that regulate neurodegenerative disease proteins has emerged as a powerful strategy to identify potential therapeutic targets for these disorders. Using cross-species genetic screens, Park et al. recently identified RAS-MAPK-MSK1 as a cellular pathway that modulates levels of the polyglutamine-containing protein ATXN1 and its subsequent toxicity in SCA1.

SUBMITTER: do Carmo Costa M 

PROVIDER: S-EPMC3790243 | biostudies-other | 2013 Oct

REPOSITORIES: biostudies-other

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