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Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma.


ABSTRACT: Prevalence of neuropathic pain is high after major surgery. However, effective treatment for preventing neuropathic pain is lacking. Here we report that perisurgical treatment of neuroprotectin D1/protectin D1 (NPD1/PD1), derived from docosahexaenoic acid, prevents nerve injury-induced mechanical allodynia and ongoing pain in mice. Intrathecal post-treatment of NPD1/PD1 also effectively reduces established neuropathic pain and produces no apparent signs of analgesic tolerance. Mechanistically, NPD1/PD1 treatment blocks nerve injury-induced long-term potentiation, glial reaction, and inflammatory responses, and reverses synaptic plasticity in the spinal cord. Thus, NPD1/PD1 and related mimetics might serve as a new class of analgesics for preventing and treating neuropathic pain.

SUBMITTER: Xu ZZ 

PROVIDER: S-EPMC3791159 | biostudies-other | 2013 Sep

REPOSITORIES: biostudies-other

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Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma.

Xu Zhen-Zhong ZZ   Liu Xing-Jun XJ   Berta Temugin T   Park Chul-Kyu CK   Lü Ning N   Serhan Charles N CN   Ji Ru-Rong RR  

Annals of neurology 20130904 3


Prevalence of neuropathic pain is high after major surgery. However, effective treatment for preventing neuropathic pain is lacking. Here we report that perisurgical treatment of neuroprotectin D1/protectin D1 (NPD1/PD1), derived from docosahexaenoic acid, prevents nerve injury-induced mechanical allodynia and ongoing pain in mice. Intrathecal post-treatment of NPD1/PD1 also effectively reduces established neuropathic pain and produces no apparent signs of analgesic tolerance. Mechanistically, N  ...[more]

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