Ontology highlight
ABSTRACT:
SUBMITTER: Xu ZZ
PROVIDER: S-EPMC3791159 | biostudies-other | 2013 Sep
REPOSITORIES: biostudies-other
Xu Zhen-Zhong ZZ Liu Xing-Jun XJ Berta Temugin T Park Chul-Kyu CK Lü Ning N Serhan Charles N CN Ji Ru-Rong RR
Annals of neurology 20130904 3
Prevalence of neuropathic pain is high after major surgery. However, effective treatment for preventing neuropathic pain is lacking. Here we report that perisurgical treatment of neuroprotectin D1/protectin D1 (NPD1/PD1), derived from docosahexaenoic acid, prevents nerve injury-induced mechanical allodynia and ongoing pain in mice. Intrathecal post-treatment of NPD1/PD1 also effectively reduces established neuropathic pain and produces no apparent signs of analgesic tolerance. Mechanistically, N ...[more]