Ontology highlight
ABSTRACT:
SUBMITTER: Pan X
PROVIDER: S-EPMC3807278 | biostudies-other | 2013 Oct
REPOSITORIES: biostudies-other
Pan Xing X Li Xiao-Jun XJ Liu Xi-Juan XJ Yuan Hui H Li Jia-Fu JF Duan Ying-Liang YL Ye Han-Qing HQ Fu Ya-Ru YR Qiao Guan-Hua GH Wu Cong-Cong CC Yang Bo B Tian Xiao-Hui XH Hu Kang-Hong KH Miao Ling-Feng LF Chen Xiao-Ling XL Zheng Jun J Rayner Simon S Schwartz Philip H PH Britt William J WJ Xu Jiang J Luo Min-Hua MH
Journal of virology 20130731 20
Congenital human cytomegalovirus (HCMV) infection is the most frequent infectious cause of birth defects, primarily neurological disorders. Neural progenitor/stem cells (NPCs) are the major cell type in the subventricular zone and are susceptible to HCMV infection. In culture, the differentiation status of NPCs may change with passage, which in turn may alter susceptibility to virus infection. Previously, only early-passage (i.e., prior to passage 9) NPCs were studied and shown to be permissive ...[more]