Unknown

Dataset Information

0

Dedicated 3D photoacoustic breast imaging.


ABSTRACT: To report the design and imaging methodology of a photoacoustic scanner dedicated to imaging hemoglobin distribution throughout a human breast.The authors developed a dedicated breast photoacoustic mammography (PAM) system using a spherical detector aperture based on our previous photoacoustic tomography scanner. The system uses 512 detectors with rectilinear scanning. The scan shape is a spiral pattern whose radius varies from 24 to 96 mm, thereby allowing a field of view that accommodates a wide range of breast sizes. The authors measured the contrast-to-noise ratio (CNR) using a target comprised of 1-mm dots printed on clear plastic. Each dot absorption coefficient was approximately the same as a 1-mm thickness of whole blood at 756 nm, the output wavelength of the Alexandrite laser used by this imaging system. The target was immersed in varying depths of an 8% solution of stock Liposyn II-20%, which mimics the attenuation of breast tissue (1.1 cm(-1)). The spatial resolution was measured using a 6 μm-diameter carbon fiber embedded in agar. The breasts of four healthy female volunteers, spanning a range of breast size from a brassiere C cup to a DD cup, were imaged using a 96-mm spiral protocol.The CNR target was clearly visualized to a depth of 53 mm. Spatial resolution, which was estimated from the full width at half-maximum of a profile across the PAM image of a carbon fiber, was 0.42 mm. In the four human volunteers, the vasculature was well visualized throughout the breast tissue, including to the chest wall.CNR, lateral field-of-view and penetration depth of our dedicated PAM scanning system is sufficient to image breasts as large as 1335 mL, which should accommodate up to 90% of the women in the United States.

SUBMITTER: Kruger RA 

PROVIDER: S-EPMC3808420 | biostudies-other | 2013 Nov

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC8885332 | biostudies-literature
| S-EPMC8847353 | biostudies-literature
| S-EPMC8655513 | biostudies-literature
| S-EPMC9980787 | biostudies-literature
| S-EPMC7082691 | biostudies-literature
| S-EPMC3959836 | biostudies-other
| S-EPMC7898616 | biostudies-literature
| S-EPMC4294657 | biostudies-literature
| S-EPMC8803813 | biostudies-literature
| S-EPMC10055152 | biostudies-literature