Ontology highlight
ABSTRACT:
SUBMITTER: Chai Z
PROVIDER: S-EPMC3810085 | biostudies-other | 2013 Nov
REPOSITORIES: biostudies-other
Chai Zhonglin Z Dai Aozhi A Tu Yugang Y Li Jiaze J Wu Tieqiao T Wang Yu Y Hale Lorna J LJ Koentgen Frank F Thomas Merlin C MC Cooper Mark E ME
Journal of the American Society of Nephrology : JASN 20130808 11
Cell division autoantigen 1 (CDA1) enhances TGF-β signaling in renal and vascular cells, and renal expression of CDA1 is elevated in animal models of diabetes. In this study, we investigated the genetic deletion of Tspyl2, the gene encoding CDA1, in C57BL6 and ApoE knockout mice. The increased renal expression of TGF-β1, TGF-β type I and II receptors, and phosphorylated Smad3 associated with diabetes in wild-type mice was attenuated in diabetic CDA1 knockout mice. Notably, CDA1 deletion signific ...[more]