Extending the cellulosome paradigm: the modular Clostridium thermocellum cellulosomal serpin PinA is a broad-spectrum inhibitor of subtilisin-like proteases.
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ABSTRACT:
SUBMITTER: O Cuiv P
PROVIDER: S-EPMC3811357 | biostudies-other | 2013 Oct
REPOSITORIES: biostudies-other
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Extending the cellulosome paradigm: the modular Clostridium thermocellum cellulosomal serpin PinA is a broad-spectrum inhibitor of subtilisin-like proteases.
O Cuív Páraic P Gupta Rajesh R Goswami Hareshwar P HP Morrison Mark M
Applied and environmental microbiology 20130719 19
Clostridium thermocellum encodes a cellulosomal, modular, and thermostable serine protease inhibitor (serpin), PinA. PinA stability but not inhibitory activity is affected by the Fn(III) and Doc(I) domains, and PinA is a broad inhibitor of subtilisin-like proteases and may play a key role in protecting the cellulosome from protease attack. ...[more]
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