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Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection.

ABSTRACT: The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a "danger response" transcription factor, c-Fos, block production of proinflammatory cytokines, and inhibit neutrophil infiltration to the site of infection.

SUBMITTER: Wilson D

PROVIDER: S-EPMC3811401 | biostudies-other | 2013 Oct

REPOSITORIES: biostudies-other

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Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection.

Wilson Duncan D Hebecker Betty B Moyes David L DL Miramón Pedro P Jablonowski Nadja N Wisgott Stephanie S Allert Stefanie S Naglik Julian R JR Hube Bernhard B

Antimicrobial agents and chemotherapy 20130729 10

The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a "danger response" transcription factor, c-Fos, block production of proinflammatory cytokines, and inhibit neutrophil infiltration to the site of infection. ...[more]

PMID: 23896471

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