Ontology highlight
ABSTRACT:
SUBMITTER: Tewari S
PROVIDER: S-EPMC3817599 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Tewari Shivendra S Parpura Vladimir V
Frontiers in computational neuroscience 20131105
The hippocampus is central to our understanding of memory formation and retrieval. Its CA1 region is known for encoding contextual memory. Here, using a computational approach, which embeds existing physiological data, we propose a particular role of astrocytes in contextual memory retrieval. We provide a quantitative framework under which the astrocyte modulates the firing of a context-associated CA1 pyramidal neurons, resulting in a prominent tuning of neurons to a delta rhythm. Using the very ...[more]