Ontology highlight
ABSTRACT:
SUBMITTER: Silva AM
PROVIDER: S-EPMC38331 | biostudies-other | 1996 Sep
REPOSITORIES: biostudies-other
Silva A M AM Lee A Y AY Gulnik S V SV Maier P P Collins J J Bhat T N TN Collins P J PJ Cachau R E RE Luker K E KE Gluzman I Y IY Francis S E SE Oksman A A Goldberg D E DE Erickson J W JW
Proceedings of the National Academy of Sciences of the United States of America 19960901 19
Plasmodium falciparum is the major causative agent of malaria, a disease of worldwide importance. Resistance to current drugs such as chloroquine and mefloquine is spreading at an alarming rate, and our antimalarial armamentarium is almost depleted. The malarial parasite encodes two homologous aspartic proteases, plasmepsins I and II, which are essential components of its hemoglobin-degradation pathway and are novel targets for antimalarial drug development. We have determined the crystal struct ...[more]