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A large prospective investigation of sleep duration, weight change, and obesity in the NIH-AARP Diet and Health Study cohort.

ABSTRACT: The relationship between sleep and obesity or weight gain in adults, particularly older populations, remains unclear. In a cohort of 83,377 US men and women aged 51-72 years, we prospectively investigated the association between self-reported sleep duration and weight change over an average of 7.5 years of follow-up (1995-2004). Participants were free of cancer, heart disease, and stroke at baseline and throughout the follow-up. We observed an inverse association between sleep duration per night and weight gain in both men (P for trend = 0.02) and women (P for trend < 0.001). Compared with 7-8 hours of sleep, shorter sleep (<5 hours or 5-6 hours) was associated with more weight gain (in kilograms; men: for <5 hours, ? = 0.66, 95% confidence interval (CI): 0.19, 1.13, and for 5-6 hours, ? = 0.12, 95% CI: -0.02, 0.26; women: for <5 hours, ? = 0.43, 95% CI: 0.00, 0.86, and for 5-6 hours, ? = 0.23, 95% CI: 0.08, 0.37). Among men and women who were not obese at baseline, participants who reported less than 5 hours of sleep per night had an approximately 40% higher risk of developing obesity than did those who reported 7-8 hours of sleep (for men, odds ratio = 1.45, 95% CI: 1.06, 1.99; for women, odds ratio = 1.37, 95% CI: 1.04, 1.79). The association between short sleep and excess weight gain was generally consistent across different categories of age, educational level, smoking status, baseline body mass index, and physical activity level.

SUBMITTER: Xiao Q

PROVIDER: S-EPMC3842900 | biostudies-other | 2013 Dec

REPOSITORIES: biostudies-other

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A large prospective investigation of sleep duration, weight change, and obesity in the NIH-AARP Diet and Health Study cohort.

Xiao Qian Q Arem Hannah H Moore Steven C SC Hollenbeck Albert R AR Matthews Charles E CE

American journal of epidemiology 20130918 11

The relationship between sleep and obesity or weight gain in adults, particularly older populations, remains unclear. In a cohort of 83,377 US men and women aged 51-72 years, we prospectively investigated the association between self-reported sleep duration and weight change over an average of 7.5 years of follow-up (1995-2004). Participants were free of cancer, heart disease, and stroke at baseline and throughout the follow-up. We observed an inverse association between sleep duration per night ...[more]

PMID: 24049160

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Project description:BackgroundThe prevalence of chronic sleep deprivation is increasing in modern societies with negative health consequences. Recently, an association between short sleep and obesity has been reported.PurposePrimary objectivesTo assess the feasibility of increasing sleep duration to a healthy length (approximately 7(1/2) h) and to determine the effect of sleep extension on body weight.Secondary objectivesTo examine the long-term effects of sleep extension on endocrine (leptin and ghrelin) and immune (cytokines) parameters, the prevalence of metabolic syndrome, body composition, psychomotor vigilance, mood, and quality of life.MethodsOne hundred-fifty obese participants who usually sleep less than 6(1/2) h, are being randomized at a 2:1 ratio to either an Intervention or to a Comparison Group. They are stratified by age (above and below 35) and the presence or absence of metabolic syndrome. During the first 12 months (Efficacy Phase) of the study, participants are evaluated at bi-monthly intervals: the Intervention Group is coached to increase sleep by at least 30-60 min/night, while the Comparison Group maintains baseline sleep duration. In the second (Effectiveness) phase, participants converge into the same group and are asked to increase (Comparison Group) or maintain (Intervention Group) sleep duration and are evaluated at 6-month intervals for an additional 3 years. Non-pharmacological and behavior-based interventions are being utilized to increase sleep duration. Endocrine, metabolic, and psychological effects are monitored. The sleep, energy expenditure, and caloric intake are assessed by activity monitors and food recall questionnaires. At yearly intervals, body composition, abdominal fat, and basal metabolic rate are measured by dual energy X-ray absorptiometry (DXA), computerized tomography (CT), and indirect calorimetry, respectively.ResultsAs of January 2010, 109 participants had been randomized, 64 to the Intervention Group and 45 to the Comparison Group (76% women, 62% minorities, average age: 40.8 years; BMI: 38.5 kg/m(2)). Average sleep duration at screening was less than 6 h/night, 40.3 h/week. A total of 28 Intervention and 22 Comparison participants had completed the Efficacy Phase.LimitationsThe study is not blinded and the sample size is relatively small.ConclusionsThis proof-of-concept study on a randomized sample will assess whether sleep extension is feasible and whether it influences BMI. Clinical Trials 2010; 7: 274-285. http://ctj.sagepub.com.

Dataset Information

A large prospective investigation of sleep duration, weight change, and obesity in the NIH-AARP Diet and Health Study cohort.

Publications

A large prospective investigation of sleep duration, weight change, and obesity in the NIH-AARP Diet and Health Study cohort.

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