Ontology highlight
ABSTRACT:
SUBMITTER: Hickey AC
PROVIDER: S-EPMC3854881 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
Hickey Andrew C AC Koster Jacob A JA Thalmann Claudia M CM Hardcastle Kathy K Tio Phaik-Hooi PH Cardosa Mary J MJ Bossart Katharine N KN
The American journal of tropical medicine and hygiene 20130923 6
Dengue virus (DENV) is considered to be the most important arthropod-borne viral disease and causes more than 100 million human infections annually. To further characterize primary DENV infection in vivo, rhesus macaques were infected with DENV-1, DENV-2, DENV-3, or DENV-4 and clinical parameters, as well as specificity and longevity of serologic responses, were assessed. Overt clinical symptoms were not present after infection. However, abnormalities in blood biochemical parameters consistent w ...[more]