Ontology highlight
ABSTRACT:
SUBMITTER: Agemy L
PROVIDER: S-EPMC3863797 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
Agemy Lilach L Kotamraju Venkata R VR Friedmann-Morvinski Dinorah D Sharma Shweta S Sugahara Kazuki N KN Ruoslahti Erkki E
Molecular therapy : the journal of the American Society of Gene Therapy 20130820 12
Antiangiogenic therapy is a promising new treatment modality for cancer, but it generally produces only transient tumor regression. We have previously devised a tumor-targeted nanosystem, in which a pentapeptide, CGKRK, delivers a proapoptotic peptide into the mitochondria of tumor blood vessel endothelial cells and tumor cells. The treatment was highly effective in glioblastoma mouse models completely refractory to other antiangiogenic treatments. Here, we identify p32/gC1qR/HABP, a mitochondri ...[more]