Ontology highlight
ABSTRACT:
SUBMITTER: Chak K
PROVIDER: S-EPMC3865755 | biostudies-other | 2014 Jan
REPOSITORIES: biostudies-other
Development (Cambridge, England) 20131127 1
The second messengers cAMP and cGMP modulate attraction and repulsion mediated by neuronal guidance cues. We find that the Drosophila receptor guanylyl cyclase Gyc76C genetically interacts with Semaphorin 1a (Sema-1a) and physically associates with the Sema-1a receptor plexin A (PlexA). PlexA regulates Gyc76C catalytic activity in vitro, and each distinct Gyc76C protein domain is crucial for regulating Gyc76C activity in vitro and motor axon guidance in vivo. The cytosolic protein dGIPC interact ...[more]