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Staphylococcal enterotoxin B influences the DNA methylation pattern in nasal polyp tissue: a preliminary study.

ABSTRACT: Staphylococcal enterotoxins may influence the pro-inflammatory pattern of chronic sinus diseases via epigenetic events. This work intended to investigate the potential of staphylococcal enterotoxin B (SEB) to induce changes in the DNA methylation pattern. Nasal polyp tissue explants were cultured in the presence and absence of SEB; genomic DNA was then isolated and used for whole genome methylation analysis. Results showed that SEB stimulation altered the methylation pattern of gene regions when compared with non stimulated tissue. Data enrichment analysis highlighted two genes: the IKBKB and STAT-5B, both playing a crucial role in T- cell maturation/activation and immune response.

SUBMITTER: Perez-Novo CA

PROVIDER: S-EPMC3867657 | biostudies-other | 2013 Dec

REPOSITORIES: biostudies-other

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Staphylococcal enterotoxin B influences the DNA methylation pattern in nasal polyp tissue: a preliminary study.

Pérez-Novo Claudina A CA Zhang Yuan Y Denil Simon S Trooskens Geert G De Meyer Tim T Van Criekinge Wim W Van Cauwenberge Paul P Zhang Luo L Bachert Claus C

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20131216 1

Staphylococcal enterotoxins may influence the pro-inflammatory pattern of chronic sinus diseases via epigenetic events. This work intended to investigate the potential of staphylococcal enterotoxin B (SEB) to induce changes in the DNA methylation pattern. Nasal polyp tissue explants were cultured in the presence and absence of SEB; genomic DNA was then isolated and used for whole genome methylation analysis. Results showed that SEB stimulation altered the methylation pattern of gene regions when ...[more]

PMID: 24341752

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