Ontology highlight
ABSTRACT:
SUBMITTER: Crump SM
PROVIDER: S-EPMC3900874 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Crump Shawn M SM Abbott Geoffrey W GW
Frontiers in genetics 20140124
There are twenty-five known inherited cardiac arrhythmia susceptibility genes, all of which encode either ion channel pore-forming subunits or proteins that regulate aspects of ion channel biology such as function, trafficking, and localization. The human KCNE gene family comprises five potassium channel regulatory subunits, sequence variants in each of which are associated with cardiac arrhythmias. KCNE gene products exhibit promiscuous partnering and in some cases ubiquitous expression, hamper ...[more]