Ontology highlight
ABSTRACT:
SUBMITTER: Hart P
PROVIDER: S-EPMC39024 | biostudies-other | 1996 Jun
REPOSITORIES: biostudies-other
Hart P P Warth J D JD Levesque P C PC Collier M L ML Geary Y Y Horowitz B B Hume J R JR
Proceedings of the National Academy of Sciences of the United States of America 19960601 13
cAMP-dependent chloride channels in heart contribute to autonomic regulation of action potential duration and membrane potential and have been inferred to be due to cardiac expression of the epithelial cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. In this report, a cDNA from rabbit ventricle was isolated and sequenced, which encodes an exon 5 splice variant (exon 5-) of CFTR, with >90% identity to human CFTR cDNA present in epithelial cells. Expression of this cDNA ...[more]