Ontology highlight
ABSTRACT:
SUBMITTER: Young E
PROVIDER: S-EPMC3911504 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
Young Evelin E Zheng Ze-Yi ZY Wilkins Angela D AD Jeong Hee-Tae HT Li Min M Lichtarge Olivier O Chang Eric C EC
Molecular and cellular biology 20131118 3
Ras can act on the plasma membrane (PM) to mediate extracellular signaling and tumorigenesis. To identify key components controlling Ras PM localization, we performed an unbiased screen to seek Schizosaccharomyces pombe mutants with reduced PM Ras. Five mutants were found with mutations affecting the same gene, S. pombe erf2 (sp-erf2), encoding sp-Erf2, a palmitoyltransferase, with various activities. sp-Erf2 localizes to the trans-Golgi compartment, a process which is mediated by its third tran ...[more]