Ontology highlight
ABSTRACT:
SUBMITTER: Kiel C
PROVIDER: S-EPMC2588540 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Kiel Christina C Aydin Dorothee D Serrano Luis L
PLoS computational biology 20081219 12
Evolutionary conservation of protein interaction properties has been shown to be a valuable indication for functional importance. Here we use homology interface modeling of 10 Ras-effector complexes by selecting ortholog proteins from 12 organisms representing the major eukaryotic branches, except plants. We find that with increasing divergence time the sequence similarity decreases with respect to the human protein, but the affinities and association rate constants are conserved as predicted by ...[more]