The ha72 core gene of baculovirus is essential for budded virus production and occlusion-derived virus embedding, and amino acid K22 plays an important role in its function.
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ABSTRACT:
SUBMITTER: Huang H
PROVIDER: S-EPMC3911753 | biostudies-other | 2014 Jan
REPOSITORIES: biostudies-other
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The ha72 core gene of baculovirus is essential for budded virus production and occlusion-derived virus embedding, and amino acid K22 plays an important role in its function.
Huang Huachao H Wang Manli M Deng Fei F Hou Dianhai D Arif Basil M BM Wang Hualin H Hu Zhihong Z
Journal of virology 20131002 1
ha72 of Helicoverpa armigera nucleopolyhedrovirus (a homologue of ac78) was identified as a conserved late baculovirus gene and characterized. HA72 localizes in the intranuclear ring zone. By generating mutants, we showed that HA72 is essential for budded virus (BD) production and occlusion-derived virus (ODV) embedding. HA72 also interacted with P33, a baculoviral sulfhydryl oxidase. A point mutation of amino acid 22 from lysine to glutamic acid curtailed BV production and precluded ODV occlusi ...[more]
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