Ontology highlight
ABSTRACT:
SUBMITTER: Handlogten MW
PROVIDER: S-EPMC3913000 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
Handlogten Michael W MW Kiziltepe Tanyel T Serezani Ana P AP Kaplan Mark H MH Bilgicer Basar B
Nature chemical biology 20131006 12
Development of specific inhibitors of allergy has had limited success, in part, owing to a lack of experimental models that reflect the complexity of allergen-IgE interactions. We designed a heterotetravalent allergen (HtTA) system, which reflects epitope heterogeneity, polyclonal response and number of immunodominant epitopes observed in natural allergens, thereby providing a physiologically relevant experimental model to study mast cell degranulation. The HtTA design revealed the importance of ...[more]