Ontology highlight
ABSTRACT:
SUBMITTER: Kalia A
PROVIDER: S-EPMC3918801 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
Kalia Amy A Lesmes Luis Andres LA Dorr Michael M Gandhi Tapan T Chatterjee Garga G Ganesh Suma S Bex Peter J PJ Sinha Pawan P
Proceedings of the National Academy of Sciences of the United States of America 20140121 5
Visual plasticity peaks during early critical periods of normal visual development. Studies in animals and humans provide converging evidence that gains in visual function are minimal and deficits are most severe when visual deprivation persists beyond the critical period. Here we demonstrate visual development in a unique sample of patients who experienced extended early-onset blindness (beginning before 1 y of age and lasting 8-17 y) before removal of bilateral cataracts. These patients show s ...[more]