Unknown

Dataset Information

0

Characterization of eosinophilic esophagitis murine models using optical coherence tomography.


ABSTRACT: Pre-clinical studies using murine models are critical for understanding the pathophysiological mechanisms underlying immune-mediated disorders such as Eosinophilic esophagitis (EoE). In this study, an optical coherence tomography (OCT) system capable of providing three-dimensional images with axial and transverse resolutions of 5 µm and 10 µm, respectively, was utilized to obtain esophageal images from a murine model of EoE-like disease ex vivo. Structural changes in the esophagus of wild-type (Tslpr(+/+) ) and mutant (Tslpr(-/-) ) mice with EoE-like disease were quantitatively evaluated and food impaction sites in the esophagus of diseased mice were monitored using OCT. Here, the capability of OCT as a label-free imaging tool devoid of tissue-processing artifacts to effectively characterize murine EoE-like disease models has been demonstrated.

SUBMITTER: Alex A 

PROVIDER: S-EPMC3920889 | biostudies-other | 2014 Feb

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC4956579 | biostudies-literature
| S-EPMC8568935 | biostudies-literature
| S-EPMC3653962 | biostudies-literature
| S-EPMC8556565 | biostudies-literature
| S-EPMC5018123 | biostudies-literature
| S-EPMC6023928 | biostudies-literature
| S-EPMC7456394 | biostudies-literature
| S-EPMC5883619 | biostudies-literature
| S-EPMC2408438 | biostudies-literature
| S-EPMC6292438 | biostudies-literature