Dataset Information

Quantification metrics for telangiectasia using optical coherence tomography.

ABSTRACT: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder that causes vascular malformations throughout the body. The most prevalent and accessible of these lesions are found throughout the skin and mucosa, and often rupture causing bleeding and anemia. A recent increase in potential HHT treatments have created a demand for quantitative metrics that can objectively measure the efficacy of new and developing treatments. We employ optical coherence tomography (OCT)-a high resolution, non-invasive imaging modality in a novel pipeline to image and quantitatively characterize dermal HHT lesion behavior over time or throughout the course of treatment. This study is aimed at detecting detailed morphological changes of dermal HHT lesions to understand the underlying dynamic processes of the disease. We present refined metrics tailored for HHT, developed from a pilot study using 3 HHT patients and 6 lesions over the course of multiple imaging dates, totalling to 26 lesion images. Preliminary results from these lesions are presented in this paper alongside representative OCT images. This study provides a new objective method to analyse and understand HHT lesions using a minimally invasive, accessible, cost-effective, and efficient imaging modality with quantitative metrics describing morphology and blood flow.

SUBMITTER: Cardinell JL

PROVIDER: S-EPMC8810896 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Quantification metrics for telangiectasia using optical coherence tomography.

Cardinell Jillian L JL Ramjist Joel M JM Chen Chaoliang C Shi Weisong W Nguyen Nhu Q NQ Yeretsian Tiffany T Choi Matthew M Chen David D Clark Dewi S DS Curtis Anne A Kim Helen H Faughnan Marie E ME Yang Victor X D VXD

Scientific reports 20220202 1

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder that causes vascular malformations throughout the body. The most prevalent and accessible of these lesions are found throughout the skin and mucosa, and often rupture causing bleeding and anemia. A recent increase in potential HHT treatments have created a demand for quantitative metrics that can objectively measure the efficacy of new and developing treatments. We employ optical coherence tomography (OCT)-a high resol ...[more]

PMID: 35110554

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Dataset Information

Quantification metrics for telangiectasia using optical coherence tomography.

Publications

Quantification metrics for telangiectasia using optical coherence tomography.

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