Ontology highlight
ABSTRACT:
SUBMITTER: San Roman AK
PROVIDER: S-EPMC3923227 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
San Roman Adrianna K AK Jayewickreme Chenura D CD Murtaugh L Charles LC Shivdasani Ramesh A RA
Stem cell reports 20140130 2
Wnt signaling is a crucial aspect of the intestinal stem cell niche required for crypt cell proliferation and differentiation. Paneth cells or subepithelial myofibroblasts are leading candidate sources of the required Wnt ligands, but this has not been tested in vivo. To abolish Wnt-ligand secretion, we used Porcupine (Porcn) conditional-null mice crossed to strains expressing inducible Cre recombinase in the epithelium, including Paneth cells (Villin-Cre (ERT2) ); in smooth muscle, including su ...[more]