Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC3926844 | biostudies-other | 2013 Dec
REPOSITORIES: biostudies-other
Chen Jinyun J Chung Franklin F Yang Guizhi G Pu Minying M Gao Hui H Jiang Wei W Yin Hong H Capka Vladimir V Kasibhatla Shailaja S Laffitte Bryan B Jaeger Savina S Pagliarini Raymond R Chen Yaoyu Y Zhou Wenlai W
Oncotarget 20131201 12
Cancer cells rely on aerobic glycolysis to maintain cell growth and proliferation via the Warburg effect. Phosphoglycerate dehydrogenase (PHDGH) catalyzes the first step of the serine biosynthetic pathway downstream of glycolysis, which is a metabolic gatekeeper both for macromolecular biosynthesis and serine-dependent DNA synthesis. Here, we report that PHDGH is overexpressed in many ER-negative human breast cancer cell lines. PHGDH knockdown in these cells leads to a reduction of serine synthe ...[more]