Ontology highlight
ABSTRACT:
SUBMITTER: Kong F
PROVIDER: S-EPMC3930622 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
Kong F F Zhang J J Li Y Y Hao X X Ren X X Li H H Zhou P P
Oncogene 20130218 8
Interrogating specific cellular activities often entails the dissection of posttranslational modifications or functional redundancy conferred by protein families, which demands more sophisticated research tools than simply eliminating a specific gene product by gene targeting or RNA interference. We have developed a novel methodology that involves engineering a single SCF(βTrCP)-based ubiquitin ligase that is capable of not only simultaneously targeting the entire family of ErbB receptor tyrosin ...[more]