Ontology highlight
ABSTRACT:
SUBMITTER: Chevalier SA
PROVIDER: S-EPMC3937318 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
Chevalier Sébastien A SA Turpin Jocelyn J Cachat Anne A Afonso Philippe V PV Gessain Antoine A Brady John N JN Pise-Masison Cynthia A CA Mahieux Renaud R
PLoS pathogens 20140227 2
Efficient HTLV-1 viral transmission occurs through cell-to-cell contacts. The Tax viral transcriptional activator protein facilitates this process. Using a comparative transcriptomic analysis, we recently identified a series of genes up-regulated in HTLV-1 Tax expressing T-lymphocytes. We focused our attention towards genes that are important for cytoskeleton dynamic and thus may possibly modulate cell-to-cell contacts. We first demonstrate that Gem, a member of the small GTP-binding proteins wi ...[more]