Ontology highlight
ABSTRACT:
SUBMITTER: Watts M
PROVIDER: S-EPMC3944880 | biostudies-other | 2014 Feb
REPOSITORIES: biostudies-other
Watts Margaret M Sherman Arthur A
Biophysical journal 20140201 3
The mechanism by which glucose induces insulin secretion in β-cells is fairly well understood. Despite years of research, however, the mechanism of glucagon secretion in α-cells is still not well established. It has been proposed that glucose regulates glucagon secretion by decreasing the conductance of either outward ATP-dependent potassium channels (K(ATP)) or an inward store-operated current (SOC). We have developed a mathematical model based on mouse data to test these hypotheses and found t ...[more]