Ontology highlight
ABSTRACT:
SUBMITTER: Herrmann RP
PROVIDER: S-EPMC3945047 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Herrmann Richard P RP Sturm Marian J MJ
Stem cells and cloning : advances and applications 20140228
Graft versus host disease is a difficult and potentially lethal complication of hematopoietic stem cell transplantation. It occurs with minor human leucocyte antigen (HLA) mismatch and is normally treated with corticosteroid and other immunosuppressive therapy. When it is refractory to steroid therapy, mortality approaches 80%. Mesenchymal stromal cells are rare cells found in bone marrow and other tissues. They can be expanded in culture and possess complex and diverse immunomodulatory activity ...[more]