Ontology highlight
ABSTRACT:
SUBMITTER: Valentino JD
PROVIDER: S-EPMC3947505 | biostudies-other | 2014 Mar
REPOSITORIES: biostudies-other
Valentino Joseph D JD Li Jing J Zaytseva Yekaterina Y YY Mustain W Conan WC Elliott Victoria A VA Kim Ji Tae JT Harris Jennifer W JW Campbell Katherine K Weiss Heidi H Wang Chi C Song Jun J Anthony Lowell L Townsend Courtney M CM Evers B Mark BM
Clinical cancer research : an official journal of the American Association for Cancer Research 20140117 5
<h4>Background</h4>The precise involvement of the PI3K/mTOR and RAS/MEK pathways in carcinoid tumors is not well defined. Therefore, the purpose of our study was to evaluate the role these pathways play in carcinoid cell proliferation, apoptosis, and secretion and to determine the effects of combined treatment on carcinoid tumor inhibition.<h4>Methods</h4>The human neuroendocrine cell lines BON (pancreatic carcinoid), NCI-H727 (lung carcinoid), and QGP-1 (somatostatinoma) were treated with eithe ...[more]