De novo design of Ln(III) coiled coils for imaging applications.
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ABSTRACT:
SUBMITTER: Berwick MR
PROVIDER: S-EPMC3950886 | biostudies-other | 2014 Jan
REPOSITORIES: biostudies-other
Publications
De novo design of Ln(III) coiled coils for imaging applications.
Berwick Matthew R MR Lewis David J DJ Jones Andrew W AW Parslow Rosemary A RA Dafforn Timothy R TR Cooper Helen J HJ Wilkie John J Pikramenou Zoe Z Britton Melanie M MM Peacock Anna F A AF
Journal of the American Chemical Society 20140116 4
A new peptide sequence (MB1) has been designed which, in the presence of a trivalent lanthanide ion, has been programmed to self-assemble to form a three stranded metallo-coiled coil, Ln(III)(MB1)3. The binding site has been incorporated into the hydrophobic core using natural amino acids, restricting water access to the lanthanide. The resulting terbium coiled coil displays luminescent properties consistent with a lack of first coordination sphere water molecules. Despite this the gadolinium co ...[more]
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