Ontology highlight
ABSTRACT:
SUBMITTER: Lu X
PROVIDER: S-EPMC395133 | biostudies-other | 1994 Jun
REPOSITORIES: biostudies-other
Lu X X Melnick M B MB Hsu J C JC Perrimon N N
The EMBO journal 19940601 11
We have identified dominant mutations that suppress the lethality associated with an R217-->L mutation in the GTP.Ras binding region (CR1) of the Drosophila raf (D-raf) serine/threonine kinase. Four intragenic and seven extragenic suppressors were recovered. Each of the four intragenic mutations contains one compensatory amino acid change located in either the CR1 or the kinase domain of D-raf. The seven extragenic suppressors represent at least four genetic loci whose effects strongly suggest t ...[more]