Ontology highlight
ABSTRACT:
SUBMITTER: Galagovsky D
PROVIDER: S-EPMC3952859 | biostudies-other | 2014 Mar
REPOSITORIES: biostudies-other
Galagovsky Diego D Katz Maximiliano J MJ Acevedo Julieta M JM Sorianello Eleonora E Glavic Alvaro A Wappner Pablo P
Molecular biology of the cell 20140115 6
Mammalian insulin-degrading enzyme (IDE) cleaves insulin, among other peptidic substrates, but its function in insulin signaling is elusive. We use the Drosophila system to define the function of IDE in the regulation of growth and metabolism. We find that either loss or gain of function of Drosophila IDE (dIDE) can restrict growth in a cell-autonomous manner by affecting both cell size and cell number. dIDE can modulate Drosophila insulin-like peptide 2 levels, thereby restricting activation of ...[more]