Ontology highlight
ABSTRACT:
SUBMITTER: Li LH
PROVIDER: S-EPMC395328 | biostudies-other | 1994 Sep
REPOSITORIES: biostudies-other
The EMBO journal 19940901 17
We show that c-Myc, in addition to activating transcription through E-box Myc binding sites (Ems), also represses transcription by a mechanism dependent on initiator (Inr) elements of the basal promoters of susceptible genes. Repression was first observed as a component of c-Myc biphasic regulation of the adenovirus-2 major late promoter (MLP), which contains both Inr and Ems sequences. Two differentiation-specific genes containing Inr, the C/EBP alpha and albumin genes, are repressed through th ...[more]