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Metformin plays a dual role in MIN6 pancreatic ? cell function through AMPK-dependent autophagy.

ABSTRACT: Metformin improves insulin sensitivity in insulin sensitive tissues such as liver, muscle and fat. However, the functional roles and the underlying mechanism of metformin action in pancreatic ? cells remain elusive. Here we show that, under normal growth condition, metformin suppresses MIN6 ? cell proliferation and promotes apoptosis via an AMPK-dependent and autophagy-mediated mechanism. On the other hand, metformin protects MIN6 cells against palmitic acid (PA)-induced apoptosis. Our findings indicate that metformin plays a dual role in ? cell survival and overdose of this anti-diabetic drug itself may lead to potential ? cell toxicity.

SUBMITTER: Jiang Y

PROVIDER: S-EPMC3957082 | biostudies-other | 2014

REPOSITORIES: biostudies-other

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Metformin plays a dual role in MIN6 pancreatic β cell function through AMPK-dependent autophagy.

Jiang Yingling Y Huang Wei W Wang Jing J Xu Zhipeng Z He Jieyu J Lin Xiaohong X Zhou Zhiguang Z Zhang Jingjing J

International journal of biological sciences 20140220 3

Metformin improves insulin sensitivity in insulin sensitive tissues such as liver, muscle and fat. However, the functional roles and the underlying mechanism of metformin action in pancreatic β cells remain elusive. Here we show that, under normal growth condition, metformin suppresses MIN6 β cell proliferation and promotes apoptosis via an AMPK-dependent and autophagy-mediated mechanism. On the other hand, metformin protects MIN6 cells against palmitic acid (PA)-induced apoptosis. Our findings ...[more]

PMID: 24644425

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