Disruption of biofilm formation by the human pathogen Acinetobacter baumannii using engineered quorum-quenching lactonases.
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ABSTRACT:
SUBMITTER: Chow JY
PROVIDER: S-EPMC3957888 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Publications
Disruption of biofilm formation by the human pathogen Acinetobacter baumannii using engineered quorum-quenching lactonases.
Chow Jeng Yeong JY Yang Yuanyong Y Tay Song Buck SB Chua Kim Lee KL Yew Wen Shan WS
Antimicrobial agents and chemotherapy 20131230 3
Acinetobacter baumannii is a major human pathogen associated with multidrug-resistant nosocomial infections; its virulence is attributed to quorum-sensing-mediated biofilm formation, and disruption of biofilm formation is an attractive antivirulence strategy. Here, we report the first successful demonstration of biofilm disruption in a clinical isolate of A. baumannii S1, using a quorum-quenching lactonase obtained by directed evolution; this engineered lactonase significantly reduced the biomas ...[more]
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