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Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells.

ABSTRACT: Immunization results in the differentiation of CD8+ T cells, such that they acquire effector abilities and convert into a memory pool. Priming of T cells takes place via an immunological synapse formed with an antigen-presenting cell (APC). By disrupting synaptic stability at different times, we found that the differentiation of CD8+ T cells required cell interactions beyond those made with APCs. We identified a critical differentiation period that required interactions between primed T cells. We found that T cell-T cell synapses had a major role in the generation of protective CD8+ T cell memory. T cell-T cell synapses allowed T cells to polarize critical secretion of interferon-? (IFN-?) toward each other. Collective activation and homotypic clustering drove cytokine sharing and acted as regulatory stimuli for T cell differentiation.

SUBMITTER: Gerard A

PROVIDER: S-EPMC3962671 | biostudies-other | 2013 Apr

REPOSITORIES: biostudies-other

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Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells.

Gérard Audrey A Khan Omar O Beemiller Peter P Oswald Erin E Hu Joyce J Matloubian Mehrdad M Krummel Matthew F MF

Nature immunology 20130310 4

Immunization results in the differentiation of CD8+ T cells, such that they acquire effector abilities and convert into a memory pool. Priming of T cells takes place via an immunological synapse formed with an antigen-presenting cell (APC). By disrupting synaptic stability at different times, we found that the differentiation of CD8+ T cells required cell interactions beyond those made with APCs. We identified a critical differentiation period that required interactions between primed T cells. W ...[more]

PMID: 23475183

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