Seminal vesicle protein SVS2 is required for sperm survival in the uterus.
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ABSTRACT:
SUBMITTER: Kawano N
PROVIDER: S-EPMC3964112 | biostudies-other | 2014 Mar
REPOSITORIES: biostudies-other
Publications
Seminal vesicle protein SVS2 is required for sperm survival in the uterus.
Kawano Natsuko N Araki Naoya N Yoshida Kaoru K Hibino Taku T Ohnami Naoko N Makino Maako M Kanai Seiya S Hasuwa Hidetoshi H Yoshida Manabu M Miyado Kenji K Umezawa Akihiro A
Proceedings of the National Academy of Sciences of the United States of America 20140303 11
In mammals, sperm migrate through the female reproductive tract to reach the egg; however, our understanding of this journey is highly limited. To shed light on this process, we focused on defining the functions of seminal vesicle secretion 2 (SVS2). SVS2(-/-) male mice produced sperm but were severely subfertile, and formation of a copulatory plug to cover the female genital opening did not occur. Surprisingly, even when artificial insemination was performed with silicon as a substitute for the ...[more]
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